Neuropathy Medications

Modified on Thu, Mar 9, 2023 at 3:40 PM

Drug Name	Drug Class	Indication	Route of Administration	Side Effects	Pregnancy Category
Gabapentin	GABA Analog	Neuropathic pain	Oral	Dizziness, drowsiness, and peripheral edema	C
Pregabalin	GABA Analog	Neuropathic pain	Oral	Dizziness, drowsiness, and dry mouth	C
Duloxetine	Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)	Diabetic neuropathy, fibromyalgia	Oral	Nausea, dry mouth, and constipation	C
Amitriptyline	Tricyclic Antidepressant	Neuropathic pain	Oral	Dry mouth, constipation, blurred vision	C
Nortriptyline	Tricyclic Antidepressant	Neuropathic pain	Oral	Dry mouth, constipation, blurred vision	D
Venlafaxine	Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)	Neuropathic pain	Oral	Nausea, dry mouth, and dizziness	C
Carbamazepine	Sodium Channel Blocker	Neuropathic pain	Oral	Dizziness, drowsiness, and nausea	D
Topiramate	Antiepileptic	Neuropathic pain	Oral	Dizziness, drowsiness, and paresthesia	D
Capsaicin	Topical Analgesic	Neuropathic pain	Topical	burning sensation, erythema, and pruritus	Not applicable
Lidocaine	Local Anesthetic	Neuropathic pain	Topical, Injection	Localized burning, swelling, and numbness	B

Drug Name	Drug Class	Indication	Route of Administration	Side Effects	Pregnancy Category
Tramadol	Opioid Analgesic	Neuropathic pain	Oral	Dizziness, drowsiness, and constipation	C
Oxycodone	Opioid Analgesic	Neuropathic pain	Oral	Nausea, constipation, and dizziness	B
Buprenorphine	Opioid Analgesic	Neuropathic pain	Transdermal Patch	Dizziness, nausea, and constipation	C
Acetaminophen	Analgesic	Neuropathic pain	Oral	Nausea, abdominal pain, rash	C
Ibuprofen	Nonsteroidal anti-inflammatory drug (NSAID)	Neuropathic pain	Oral	Nausea, stomach pain, headache	D
Ketamine	NMDA receptor antagonist	Neuropathic pain	Injection	Nausea, vomiting, and hallucinations	C
Tizanidine	Alpha-2 Adrenergic Agonist	Neuropathic pain	Oral	Drowsiness, dry mouth, and dizziness	C
Clonidine	Alpha-2 Adrenergic Agonist	Neuropathic pain	Oral, transdermal patch	Drowsiness, dry mouth, constipation	C
Ziconotide	N-type Calcium Channel Blocker	Neuropathic pain	Intrathecal	Dizziness, nausea, confusion	C
Alpha-Lipoic Acid	Antioxidant	Diabetic neuropathy	Oral	Nausea, abdominal pain, rash	C

Please be aware that there are numerous additional medications and treatments for neuropathy, and this list is not all-inclusive. Additionally, because they are subject to change as new research becomes available, the categories for side effects and pregnancy listed here may not be current.