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Thyroid Disorders

Modified on Tue, Feb 28, 2023 at 11:40 AM

Thyroid disorders are conditions that affect the thyroid gland, a small gland in the neck that regulates the body's metabolism by producing hormones. Multiple types of thyroid disorders exist, including: 

  • Hypothyroidism is a condition in which the thyroid gland fails to produce sufficient amounts of thyroid hormones. Fatigue, weight gain, cold intolerance, constipation, dry skin, and depression may be symptoms of hypothyroidism. In hyperthyroidism, the thyroid gland produces an excessive amount of thyroid hormone. 

  • Hyperthyroidism can cause weight loss, a rapid heartbeat, tremors, anxiety, and difficulty sleeping. Nodules on the thyroid are lumps or growths on the thyroid gland. The majority of thyroid nodules are benign, but some can be malignant. This is inflammation of the thyroid gland, or thyroiditis. Infection, autoimmune disease, or radiation therapy may cause it. 


Thyroid disorders are typically diagnosed through a combination of physical examination, blood tests, and imaging studies. The following blood tests are commonly used to diagnose thyroid disorders: 

  • This test measures the level of thyroid-stimulating hormone (TSH) in the blood. TSH is a hormone produced by the pituitary gland that stimulates the production of thyroid hormones by the thyroid gland. TSH levels that are high may indicate hypothyroidism, whereas TSH levels that are low may indicate hyperthyroidism. 

  • This test measures the concentration of thyroxine (T4) in the bloodstream. T4 is an important thyroid hormone. Hypothyroidism may be indicated by low T4 levels, while hyperthyroidism may be indicated by high T4 levels. 

  • This test measures the blood concentration of triiodothyronine (T3). Another thyroid hormone is T3. High T3 levels may be indicative of hyperthyroidism. 

  • These tests measure the concentration of antibodies that attack the thyroid gland. These tests can assist in the diagnosis of autoimmune thyroid conditions such as Hashimoto's thyroiditis and Graves' disease. 

The following imaging studies are commonly used to diagnose thyroid disorders: 

Ultrasound: This imaging test creates images of the thyroid gland using sound waves. It can be utilized to detect nodules and other abnormalities. This test requires the ingestion of a small amount of radioactive iodine, which is absorbed by the thyroid gland. The thyroid gland is then imaged using a specialized camera, which can help identify nodules or areas of abnormal activity. Thyroid disorders are treated based on the specific condition and its severity.

 Possible therapeutic options include: Hormone replacement therapy is frequently used to treat hypothyroidism, whereas medications that inhibit the production of thyroid hormones may be used to treat hyperthyroidism. This treatment consists of taking a large dose of radioactive iodine, which kills thyroid cells. It is a common treatment for hyperthyroidism. 


In some instances, surgery may be required to remove all or a portion of the thyroid gland. In some instances, thyroid nodules or other abnormalities may not require treatment but are instead monitored over time to ensure that they do not become cancerous or cause other complications. 



References

Silvia, Alda, Andrea, & Poupak. (2015). Autoimmunity reviews 14 no.
Ambika, & Usha. (2011). Indian journal of endocrinology and metabolism 15 no.
Rosa, & Alexandra. (2012). Thyroid disorders.
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Michael, & Kristien. (2015). The lancet Diabetes  endocrinology 3 no.
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Martin, Inder, Cary, John, & David. (1990). Jama 263 no.
Mira, & Sami. (2011). Thyroid disorders and diabetes mellitus.
Vanderpump. (1995). Clinical endocrinology 43 no.


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